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At APEX Mycology, we believe in transparency and sharing knowledge. Below you’ll find a summary of independent scientific studies that have explored various aspects of Hericium erinaceus (commonly known as Lion’s Mane mushroom). These studies include lab-based research, animal models, and small-scale human trials conducted by external researchers. The findings cover a wide range of topics including composition, traditional use, and biological activity.
This page is for informational purposes only and is intended to give insight into the broader academic interest surrounding Lion’s Mane mushrooms.
The summaries presented here are based on independent, third-party research and do not relate to any specific APEX Mycology product. We do not make any health or medicinal claims. Our products are sold as food supplements and should not be used as a substitute for a varied, balanced diet or a healthy lifestyle. The content on this page is not intended to diagnose, treat, cure, or prevent any disease.
Always consult a qualified healthcare professional before making changes to your diet or supplement routine.
Memory & Cognitive Function
A clinical study on how Lion’s Mane mushroom affected memory and thinking in older adults with mild cognitive issues.
Conclusion by Authors:
The study observed a reversible improvement in cognitive function scores among participants taking Hericium erinaceus (Lion's Mane), with no serious adverse effects reported during the study period.
Depression and Anxiety
Study of the potential for reduction of depression and anxiety by 4 Weeks Hericium erinaceus Intake.
Conclusion by Authors:
The study observed reductions in CES-D and ICI scores in the group that consumed Hericium erinaceus. The results suggest that this mushroom may influence certain psychological and physiological indicators.
Neuroregenerative Potential
A pre-clinical in vivo study using Sprague-Dawley rats. The aim was to evaluate the effects of an aqueous extract of Hericium erinaceus fresh fruit bodies on recovery from crush injury to the peroneal nerve.
Conclusion by Authors:
Daily oral intake of Lion’s Mane helped rats recover faster from peripheral nerve injury. The effects were similar to those of mecobalamin, a known nerve repair aid, but without reported side effects. The authors suggest this extract could be useful for supporting nerve recovery and recommend further studies.
Neurotrophic and Neuroprotective Properties
A comprehensive literature review of in vitro, in vivo (animal), and human studies related to the neurotrophic and neuroprotective properties of Hericium erinaceus (Lion’s Mane mushroom).
Conclusion by Authors:
The review concludes that Hericium erinaceus exhibits multiple neurotrophic and neuroprotective properties based on a wide body of preclinical and limited clinical evidence.
Immunomodulatory Effects
Researchers studied how a water-soluble extract from the fruiting bodies of Hericium erinaceus (Lion’s Mane mushroom), specifically its polysaccharides, affected immune activity in mice.
Conclusion:
This animal study showed that oral intake of Hericium erinaceus polysaccharides enhanced both innate and adaptive immune responses in mice, especially through their effects on gut-associated immune activity. The extract activated several immune pathways and increased key immune markers without any observed toxicity.
These findings suggest that the immunomodulatory effects of Lion’s Mane may be linked to its impact on intestinal immune processes. Further research is needed to explore these effects in humans.
Heart and Blood Vessel Health
Researchers investigated whether different extracts from Lion’s Mane mushroom (Hericium erinaceus) could affect two key processes linked to heart and blood vessel health—oxidation of LDL (“bad” cholesterol) and the activity of an enzyme involved in cholesterol production (HMG Co-A reductase).
Conclusion:
This laboratory study found that certain components of Lion’s Mane mushroom may influence cholesterol-related processes in vitro. These findings highlight interesting areas for future research, but further studies—particularly in humans—are needed to understand their relevance and potential applications.
Cognitive Function and Stress
A 2023 randomized, double-blind, placebo-controlled trial investigated the impact of Hericium erinaceus (Lion’s Mane) supplementation on cognitive performance and stress levels in healthy adults. Over an 8-week period, participants who supplemented with Lion’s Mane showed significant improvements in memory, concentration, and overall cognitive function, along with notable reductions in perceived stress when compared to the placebo group.
This study highlights the potential role of Lion’s Mane in supporting cognitive resilience and mental wellbeing, likely linked to its influence on nerve growth factor (NGF) synthesis and neuroprotective activity.
The Lion’s Mane used in the study was derived from the whole fruiting body — aligning with the product we proudly offer.
Conclusion:
"Our findings suggest that daily supplementation with Hericium erinaceus improves cognitive performance and reduces stress in healthy adults. These results support the traditional use of Lion’s Mane for cognitive and emotional wellbeing and indicate its potential as a natural nootropic agent.”
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